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Title: Camptothecin and 9-methoxy camptothecin, anti-cancer alkaloids in Nothapodytes nimmoniana Graham. from Western Ghats, India
Authors: P, Kavitha
T, Vasanthakumar
P E, Rajasekharan
V K, Abdul Kareem
V K, Rao
Keywords: Camptothecin
Nothapodytes nimmoniana
Issue Date: 2010
Citation: P. Kavitha, T.Vasantha Kumar, P.E. Rajasekharan, V.K. Abdul Kareem And V.K. Rao. 2010. Camptothecin and 9-methoxy camptothecin, anti-cancer alkaloids in Nothapodytes nimmoniana Graham. from Western Ghats, India.Journal of Medicinal and Aromatic Plant Sciences 32 (2) : 129-132
Abstract: : Nothapodytes nimmoniana is a well known natural source of Camptothecin (CPT), a monoterpene indole alkaloid which exhibits antitumor activity. Its analogs are potent antiviral, anti-HIV agents and chemosterilants. Because of the extensive use of CPT and with no synthetic sources of this alkaloid, world demand of CPT has increased leading to decline in natural populations of N. nimmoniana. Prospecting for populations/ individuals of the species for higher yields of the alkaloid could help in establishing high-yielding clonal orchards and in developing in vitro production systems. Towards this direction 48 individual trees of N.nimmoniana were chemically profiled from five localities of Western Ghats of Karnataka state. There was significant variation in both CPT and 9-methoxy CPT (9-MCPT) contents in stem bark and root bark samples. Among the different plant parts tested the average accumulation of both CPT and 9-MCPT was high in root bark (0.28 % and 0.09 %) followed by stem bark (0.24 and 0.09 %), stem ((0.12 and 0.04 %) and leaves (0.08 and 0.006 %). Correlation analysis between CPT and 9-MCPT revealed that there is a linear relationship between accumulation of CPT and 9-MCPT in stem, stem bark and root bark but not in leaves. Four individuals with high CPT content (0.7 to 1.11 %) were found to be good source material for clonal multiplication and in vitro production systems.
URI: http://hdl.handle.net/123456789/93
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